Stage 4 gets off to an uphill start, following the kick-off in front of MART, the famous museum of modern art in Rovereto. After the first few flat kilometres, the riders will have to tackle the long climb up to the Passo Sommo (1341 m asl). The gradients are regular, but it still is more than 15 km of climbing. And even for the rest of the stage, there will be little flatness.

After passing the ascent of the Santa Colomba lake, the route winds its way along both sides of the Cembra Valley, switching between uphill segments and short descents. Entering Fiemme Valley, rider will face the climb to the Pramadiccio Pass, introduced by the characteristic 'Della Cascata' (Of the Waterfall) climb, the iconic and decisive ascent of the Marcialonga. The last KOM is located 15 km from the finish line, which include a very fast downhill section towards Tesero, and a flat segment towards Predazzo, with the last kilometre slightly uphill.